TOX2

TOX2
Identifiers
Aliases	TOX2, C20orf100, GCX-1, GCX1, dJ1108D11.2, dJ495O3.1, TOX high mobility group box family member 2
External IDs	OMIM: 611163; MGI: 3611233; GeneCards: TOX2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,069,616 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,166,090 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; thymus; ; gastric mucosa; ; right lung; ; lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; hypothalamus; ; Descending thoracic aorta; ; pituitary gland;
	Top expressed in
	cumulus cell; ; dorsomedial hypothalamic nucleus; ; median eminence; ; substantia nigra; ; suprachiasmatic nucleus; ; nucleus of stria terminalis; ; central gray substance of midbrain; ; mesenteric lymph nodes; ; ventromedial nucleus; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84969
	269389
	ENSG00000124191
	ENSMUSG00000074607
	Q96NM4
	n/a
	NM_001098796; NM_001098797; NM_001098798; NM_032883
NM_001098799; NM_001363063; NM_001363064; NM_001372575; NM_001372576;
	NM_001372577; NM_001372578; NM_001372579; NM_001372580
	NP_001092266; NP_001092267; NP_001092268; NP_116272
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

TOX high mobility group box family member 2, also known as TOX2, is a protein that in humans is encoded by the gene TOX2.^[5]^[6]

The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX3, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124191 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074607 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TOX high mobility group box family member 2".
↑ Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K (May 2004). "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells". Endocrinology. 145 (5): 2307–18. doi:10.1210/en.2003-1343. PMID 14764631. S2CID 25037508.
↑ O'Flaherty E, Kaye J (April 2003). "TOX defines a conserved subfamily of HMG-box proteins". BMC Genomics. 4 (1) 13. doi:10.1186/1471-2164-4-13. PMC 155677. PMID 12697058.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124191 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074607 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_84969-5] "Entrez Gene: TOX high mobility group box family member 2".

[pmid14764631-6] Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K (May 2004). "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells". Endocrinology. 145 (5): 2307–18. doi:10.1210/en.2003-1343. PMID 14764631. S2CID 25037508.

[pmid12697058-7] O'Flaherty E, Kaye J (April 2003). "TOX defines a conserved subfamily of HMG-box proteins". BMC Genomics. 4 (1) 13. doi:10.1186/1471-2164-4-13. PMC 155677. PMID 12697058.

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