CEBPE

CEBPE
Identifiers
Aliases	CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon, CCAAT enhancer binding protein epsilon, c/EBP epsilon
External IDs	OMIM: 600749; MGI: 103572; GeneCards: CEBPE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T92
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 23,117,036 bp End 23,120,256 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C2|14 27.9 cM Start 54,947,817 bp End 54,949,631 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow trabecular bone bone marrow cell gonad blood monocyte granulocyte vena cava spleen duodenum Top expressed in granulocyte bone marrow embryo liver jejunum ileum spleen lip quadriceps femoris muscle colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein homodimerization activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process defense response myeloid cell differentiation positive regulation of gene expression cellular response to lipopolysaccharide regulation of transcription, DNA-templated defense response to bacterium transcription, DNA-templated positive regulation of transcription by RNA polymerase II macrophage differentiation phagocytosis transcription by RNA polymerase II granulocyte differentiation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1053 110794 Ensembl ENSG00000092067 ENSMUSG00000052435 UniProt Q15744 Q6PZD9 RefSeq (mRNA) NM_001805 NM_207131 RefSeq (protein) NP_001796 NP_997014 Location (UCSC) Chr 14: 23.12 – 23.12 Mb Chr 14: 54.95 – 54.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of CCAAT-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic.

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.

Further reading

• Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
• Gombart AF, Koeffler HP (Jan 2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Current Opinion in Hematology. 9 (1): 36–42. doi:10.1097/00062752-200201000-00007. PMID 11753076. S2CID 25411864.
• Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553.