IKZF3

IKZF3
Identifiers
Aliases	IKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3, IMD84
External IDs	OMIM: 606221; MGI: 1342542; GeneCards: IKZF3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,864,312 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,436,857 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; epithelium of nasopharynx; ; bone marrow cell; ; thymus; ; spleen; ; blood; ; tonsil; ; superficial temporal artery; ; appendix;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; spleen; ; blood; ; lumbar subsegment of spinal cord; ; female urethra; ; subcutaneous adipose tissue; ; submandibular gland; ; granulocyte; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; nucleic acid binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; plasma membrane; nucleus; nucleoplasm; cytosol;
Biological process	regulation of apoptotic process; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; B cell activation; regulation of B cell proliferation; regulation of lymphocyte differentiation; mesoderm development; regulation of B cell differentiation; positive regulation of transcription by RNA polymerase II; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22806
	22780
	ENSG00000161405
	ENSMUSG00000018168
	Q9UKT9
	O08900
NM_183232; NM_001257408; NM_001257409; NM_001257410; NM_001257411;
	NM_001257412; NM_001257413; NM_001257414; NM_001284514; NM_001284515; NM_001284516; NM_012481; NM_183228; NM_183229; NM_183230; NM_183231
	NM_011771
NP_001244337; NP_001244338; NP_001244339; NP_001244340; NP_001244341;
	NP_001244342; NP_001244343; NP_001271443; NP_001271444; NP_001271445; NP_036613; NP_899051; NP_899052; NP_899053; NP_899054; NP_899055
	NP_035901
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Aiolos, also known as Ikaros family zinc finger protein 3, is a protein encoded in humans by the IKZF3 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. The regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.^[7]

Interactions

IKZF3 has been shown to interact with BCL2-like 1^[8] and HRAS.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161405 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018168 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (April 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803. PMID 9155026.
↑ Hosokawa Y, Maeda Y, Takahashi EI, Suzuki M, Seto M (November 1999). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935.
1 2 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".
↑ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. hdl:10481/100807. PMID 11714801.
↑ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.

Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P (February 2003). "Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice". Journal of Immunology. 170 (4): 1699–706. doi:10.4049/jimmunol.170.4.1699. PMID 12574333. S2CID 31136931.
Schmitt C, Tonnelle C, Dalloul A, Chabannon C, Debré P, Rebollo A (June 2002). "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation". Apoptosis. 7 (3): 277–84. doi:10.1023/A:1015372322419. PMID 11997672. S2CID 1318582.
Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K (October 1998). "Aiolos regulates B cell activation and maturation to effector state". Immunity. 9 (4): 543–53. doi:10.1016/S1074-7613(00)80637-8. PMID 9806640.
Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K (March 1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity. 10 (3): 345–55. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.
Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.
Koipally J, Georgopoulos K (June 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161405 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9155026-5] Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (April 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803. PMID 9155026.

[pmid10552935-6] Hosokawa Y, Maeda Y, Takahashi EI, Suzuki M, Seto M (November 1999). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935.

[entrez-7] 1 2 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".

[pmid11714801-8] Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. hdl:10481/100807. PMID 11714801.

[pmid10369681-9] Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Function

Interactions

References

Further reading