Fenibut

Fenibut
(IUPAC) ime
	(RS)-4-amino-3-fenil-buterna kiselina
Klinički podaci
Identifikatori
CAS broj	1078-21-3
ATC kod	nije dodeljen
PubChem	14113
ChemSpider	13491
ChEMBL	CHEMBL315818
Hemijski podaci
Formula	C10H13NO2
Mol. masa	179,216 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13) ; Key: DAFOCGYVTAOKAJ-UHFFFAOYSA-N
Sinonimi	Fenibut, Phenybut, PhGABA
Fizički podaci
Tačka topljenja	253 °C (487 °F)
Farmakokinetički podaci
Poluvreme eliminacije	5 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	OTC (SAD)
Način primene	Oralno

β-Fenil-γ-aminobuterna kiselina (fenibut) je derivat prirodnog inhibitornog neurotransmitera γ-minobuterne kiseline (GABA). Dodatak fenilnog prstena omogućava fenibutu da prođe kroz krvno-moždanu barijeru.^[5] Fenibut je u prodaji kao prehrambeni suplement.^[6] On nije odobren za uporebu kao lek u SAD-u i Evropi, mada se u Rusiji prodaje kao neuropihotropni lek. Postoje izveštaji po kojima on poseduje nootropna svojsta i da ima sposobnost poboljšanja neuroloških funkcija,^[7] međutim postoje i dijametralno suprotni nalazi.^[8] Generalno je prihavaćeno da fenibut ima anksiolitičko dejstvo kod životinja i ljudi.^[5] Fenibut je otriven u Sovjetskom Savezu tokom 1960-tih, i od tog vremena je korišten za tretiranje širokog opsega bolesti uključujući posttraumatski stres, anksioznost i insomniju.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
1 2 Lapin, I. (2001). „Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug” (pdf). CNS Drug Reviews 7 (4): 471–481. DOI:10.1111/j.1527-3458.2001.tb00211.x. PMID 11830761.
↑ Nelson, LS (2008). „Phenibut Withdrawal - A Novel 'Nutritional Supplement'”. Clinical Toxicology 46 (7): 605. ^{[mrtav link]}
1 2 Shulgina, G. I. (1986). „On neurotransmitter mechanisms of reinforcement and internal inhibition”. The Pavlovian journal of biological science 21 (4): 129–140. DOI:10.1007/BF02734511. ISSN 0093-2213. PMID 2431377.
↑ Kovaleva, E. L. (1984). „Comparative characteristics of the nootropic action of fenibut and fepiron”. Farmakologiia i toksikologiia 47 (1): 20–23. PMID 6705902.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[LapinI2001-5] 1 2 Lapin, I. (2001). „Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug” (pdf). CNS Drug Reviews 7 (4): 471–481. DOI:10.1111/j.1527-3458.2001.tb00211.x. PMID 11830761.

[NelsonLS2008-6] Nelson, LS (2008). „Phenibut Withdrawal - A Novel 'Nutritional Supplement'”. Clinical Toxicology 46 (7): 605. ^{[mrtav link]}

[ShulginaGI1986-7] 1 2 Shulgina, G. I. (1986). „On neurotransmitter mechanisms of reinforcement and internal inhibition”. The Pavlovian journal of biological science 21 (4): 129–140. DOI:10.1007/BF02734511. ISSN 0093-2213. PMID 2431377.

[KovalevaEL1984-8] Kovaleva, E. L. (1984). „Comparative characteristics of the nootropic action of fenibut and fepiron”. Farmakologiia i toksikologiia 47 (1): 20–23. PMID 6705902.

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