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. 1997 Aug;7(2):283-90.
doi: 10.1016/s1074-7613(00)80530-0.

LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

L Meyaard  1 , G J Adema, C Chang, E Woollatt, G R Sutherland, L L Lanier, J H Phillips
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Free article

LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

L Meyaard et al. Immunity. 1997 Aug.
Free article

Abstract

In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

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