Erreelina

RELN
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	2ddu, 2e26, 2DDU, 2E26, 3A7Q
Identifikatzaileak
Aliasak	RELN (HUGO), LIS2, PRO1598, RL, reelin, ETL7
Kanpoko IDak	OMIM: 600514 MGI: 103022 HomoloGene: 3699 GeneCards: RELN OMA: RELN - orthologs
Genetikoki lotutako gaixotasunak
	Alzheimer, Otosklerosi, esklerosi anizkoitz, eskizofrenia, Norman–Roberts syndrome , familial temporal lobe epilepsy 7
Genearen kokapena (gizakia)
	Kromosoma: 7 (gizakia)
Amaiera	103.989.658 bp
Genearen kokapena (sagua)
	Kromosoma: 5 (sagua)
Amaiera	22.549.700 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	Usaimen-erraboil; ; Bermis; ; cerebellar hemisphere ; ; paraflocculus of cerebellum ; ; right hemisphere of cerebellum ; ; spinal ganglia ; ; trigeminal ganglion ; ; endothelial cell ; ; Nerbio tibial ; ; Entzefaloaren enborreko zubia;
	Adierazpen ohikoena
	gorputz ziliar; ; Bermis; ; lobe of cerebellum ; ; Iris; ; Usaimen-erraboil; ; nerbio ziatiko; ; endothelial cell of lymphatic vessel ; ; superior colliculus ; ; paraventricular nucleus of hypothalamus ; ; piriform cortex ;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	metal ion binding ; peptidase activity ; hydrolase activity ; serine-type peptidase activity ; lipoprotein particle receptor binding ; very-low-density lipoprotein particle receptor binding ;
Zelularen osagaia	zitoplasma ; Dendrita ; zelula mintz ; zelulaz kanpoko eremu ; extracellular space ; mintza ; Zelula kanpoko matrize ; neuron projection ;
Prozesu biologikoa	NMDA glutamate receptor clustering ; positive regulation of lateral motor column neuron migration ; dendrite development ; proteolisi ; cerebral cortex development ; lateral motor column neuron migration ; positive regulation of phosphatidylinositol 3-kinase signaling ; positive regulation of TOR signaling ; Iraupen luzeko oroimen ; izaki zelulanitzen garapena ; receptor localization to synapse ; postsynaptic density protein 95 clustering ; ventral spinal cord development ; protein localization to synapse ; forebrain development ; long-term potentiation ; gene-erregulazio ; layer formation in cerebral cortex ; cell migration ; ikaskuntza ; associative learning ; Atxikipen zelular ; hippocampus development ; spinal cord patterning ; cerebral cortex tangential migration ; positive regulation of peptidyl-tyrosine phosphorylation ; glial cell differentiation ; peptidyl-tyrosine phosphorylation ; positive regulation of excitatory postsynaptic potential ; positive regulation of CREB transcription factor activity ; positive regulation of protein kinase activity ; modulation of chemical synaptic transmission ; positive regulation of AMPA receptor activity ; brain development ; central nervous system development ; response to pain ; positive regulation of synapse maturation ; positive regulation of long-term synaptic potentiation ; cell morphogenesis involved in differentiation ; neuron migration ; positive regulation of neuron projection development ; positive regulation of small GTPase mediated signal transduction ; positive regulation of synaptic transmission, glutamatergic ; regulation of behavior ; positive regulation of dendritic spine morphogenesis ; reelin-mediated signaling pathway ; regulation of NMDA receptor activity ; positive regulation of protein tyrosine kinase activity ; axon guidance ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	5649
	19699
	ENSG00000189056
	ENSMUSG00000042453
	P78509
	Q60841
	NM_173054; NM_005045
	NM_011261; NM_001310464
	NP_005036; NP_774959
	NP_001297393; NP_035391
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Erreelina batez ere garunean dago, baita bizkarrezur-muinean, odolean eta beste organo eta ehun batzuetan ere dagoen proteina bat da. Funtsezkoa da neurona-migrazioko eta posizionamenduko prozesuak erregulatzeko garunaren enbrioi-garapenean, eta etapa horretan Cajal-Retziusen neuronek sortzen dute nagusiki. Garapen goiztiarreko zeregin garrantzitsu horretaz gain, erreelinak garun helduan lan egiten jarraitzen du, plastikotasun sinaptikoa modulatuz eta indukzioa eta LTP mantentzea hobetuz.^[6]^[7]

Erreferentziak

↑ Genetikoki lotutako gaixotasunak RELNikusi/editatu erreferentziak Wikidatan. .
1 2 3 GRCh38: Ensembl release 89: ENSG00000189056 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042453 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Ingelesez) Weeber EJ, Beffert U, Jones C, et al. (2002ko urria). «Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning» J. Biol. Chem. 277 (42): 39944–52. doi:10.1074/jbc.M205147200. PMID 12167620..
↑ (Ingelesez) D'Arcangelo G. (2005eko abuztua). «Apoer2: a reelin receptor to remember» Neuron 47 (4): 471–3. doi:10.1016/j.neuron.2005.08.001. PMID 16102527..

Kanpo estekak

Datuak: Q13561329
Multimedia: Reelin / Q13561329

[1] Genetikoki lotutako gaixotasunak RELNikusi/editatu erreferentziak Wikidatan. .

[refGRCh38Ensembl-2] 1 2 3 GRCh38: Ensembl release 89: ENSG00000189056 - Ensembl, May 2017

[refGRCm38Ensembl-3] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042453 – Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[LTP1-6] (Ingelesez) Weeber EJ, Beffert U, Jones C, et al. (2002ko urria). «Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning» J. Biol. Chem. 277 (42): 39944–52. doi:10.1074/jbc.M205147200. PMID 12167620..

[LTP2-7] (Ingelesez) D'Arcangelo G. (2005eko abuztua). «Apoer2: a reelin receptor to remember» Neuron 47 (4): 471–3. doi:10.1016/j.neuron.2005.08.001. PMID 16102527..

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