INSL5

INSL5
Identifiers
Aliases	INSL5, PRO182, UNQ156, insulin like 5
External IDs	OMIM: 606413; MGI: 1346085; GeneCards: INSL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1V, 2KBC
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 66,797,740 bp End 66,801,276 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C6|4 47.27 cM Start 102,875,069 bp End 102,884,039 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of sigmoid colon testicle mucosa of transverse colon right uterine tube hypothalamus Brodmann area 9 nucleus accumbens hippocampus proper muscle tissue Top expressed in left colon neural layer of retina epithelium of small intestine thymus embryo embryo spermatid inner nuclear layer enteric nervous system outer nuclear layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity G protein-coupled receptor binding Cellular component extracellular region cellular component Biological process positive regulation of feeding behavior regulation of signaling receptor activity G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10022 23919 Ensembl ENSG00000172410 ENSMUSG00000066090 UniProt Q9Y5Q6 Q9WUG6 RefSeq (mRNA) NM_005478 NM_001290648 NM_011831 RefSeq (protein) NP_005469 NP_001277577 NP_035961 Location (UCSC) Chr 1: 66.8 – 66.8 Mb Chr 4: 102.88 – 102.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Insulin-like peptide 5 (INSL5) is a hormone that in humans is encoded by the INSL5 gene. This hormone is secreted by the large intestines and activates the RXFP4 receptor with high affinity. It may be involved in regulating intestinal contractions or the development of the thymus.

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin-3 (RLN3/INSL7).

Further reading

• Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Koman A, Cazaubon S, Couraud PO, Ullrich A, Strosberg AD (August 1996). "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family". The Journal of Biological Chemistry. 271 (34): 20238–41. doi:10.1074/jbc.271.34.20238. PMID 8702754.

External links

• INSL5 human gene location in the UCSC Genome Browser.
• INSL5 human gene details in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9Y5Q6 (Human Insulin-like peptide INSL5) at the PDBe-KB.