ADP deaminase
| ADP deaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.4.7 | ||||||||
| CAS no. | 9027-79-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
ADP deaminase (EC 3.5.4.7) is an enzyme first characterised from rabbit muscle that catalyzes the hydrolysis of adenosine diphosphate (ADP) to inosine diphosphate and ammonia as part of the metabolism of purine nucleotides:[1][2][3]
The reaction has been used in an assay for ADP.[4]
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is ADP aminohydrolase. Other names in common use include adenosine diphosphate deaminase, and adenosinepyrophosphate deaminase.[5]
Isozymes
[edit]This type of enzyme activity was reported in rabbits and certain fungi (aspergillus) in two papers from 1967 and 1968,[6] but currently no identified proteins of this type are listed in databases like uniprot/expasy.[7]
See also
[edit]- AMP deaminase which hydrolyses adenosine monophosphate to inosine monophosphate
References
[edit]- ↑ Deutsch A, Nilsson R (1954). "On the dephosphorylation and deamination of adenosine triphosphate by actomyosin gel". Acta Chem. Scand. 8: 1898–1906. doi:10.3891/acta.chem.scand.08-1898.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "ADP deaminase". Enzyme Handbook 4. pp. 1015–1018. doi:10.1007/978-3-642-84437-9_202. ISBN 978-3-642-48986-0.
- ↑ Sillero, Antonio; María, A.; Sillero, Günther (2018). "Purine Nucleotide Metabolism in Artemia". Biochemistry and Cell Biology of Artemia. pp. 95–112. doi:10.1201/9781351070157-4. ISBN 978-1-351-07015-7.
- ↑ Brown, Phyllis R. (1970). "The rapid separation of nucleotides in cell extracts using high-pressure liquid chromatography". Journal of Chromatography A. 52 (2): 257–272. doi:10.1016/S0021-9673(01)96573-2. PMID 5474279.
- ↑ Enzyme 3.5.4.7 at KEGG Pathway Database.
- ↑ BRENDA online database for enzymes: 3.5.4.7
- ↑ EC 3.5.4.7
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