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Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10

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Somatic Cell and Molecular Genetics

Abstract

Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3′ untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Lederle Graduate Research Center, University of Massachusetts, Amherst, Massachusetts

    Asha K. Kamat

  2. Instituto di Genetica, Universita degli studi di Bari, via Amendola 165/A, 70/26, Bari, Italy

    Mariano Rocchi

  3. Department of Molecular Biology and Genetics, Wayne State University, School of Medicine, Detroit, Michigan

    David I. Smith & Orlando J. Miller

Authors
  1. Asha K. Kamat
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  2. Mariano Rocchi
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  3. David I. Smith
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  4. Orlando J. Miller
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Kamat, A.K., Rocchi, M., Smith, D.I. et al. Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. Somat Cell Mol Genet 19, 203–208 (1993). https://doi.org/10.1007/BF01233534

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  • DOI: https://doi.org/10.1007/BF01233534

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