SATB2

SATB2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1WI3, 1WIZ, 2CSF
Identifikatori
Aliasi	SATB2
Vanjski ID-jevi	OMIM: 608148 MGI: 2679336 HomoloGene: 32249 GeneCards: SATB2
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	199,471,266 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	57,017,809 bp
Ontologija gena
Molekularna funkcija	• sequence-specific DNA binding; • vezivanje sa DNK; • chromatin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• histone deacetylase complex; • transcription regulator complex; • nuclear matrix; • jedro; • nukleoplazma;
Biološki proces	• commitment of neuronal cell to specific neuron type in forebrain; • embryonic skeletal system morphogenesis; • cellular response to organic substance; • Wikipedia:Igralište/Remodeliranje hromatina; • roof of mouth development; • GO:0009373 regulation of transcription, DNA-templated; • embryonic pattern specification; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • neuron migration; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • multicellular organism development; • cartilage development; • Regulacija ekspresije gena; • osteoblast development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	23314
	212712
	ENSG00000119042
	ENSMUSG00000038331
	Q9UPW6
	Q8VI24
	NM_001172509; NM_001172517; NM_015265
	NM_139146; NM_001358580; NM_001358581
	NP_001165980; NP_001165988; NP_056080
	NP_631885; NP_001345509; NP_001345510
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

SPATS2-liki protein (spermatogenezi pridruženi, serin-bogati 2-liki protein) ili DNAPTP6 (DNK-polimerazno transaktivirtani protein 6) jest protein koji je kod ljudi kodiran genom SPATS2L sa hromosoma 2..^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 558 aminokiselina, a molekulska težina 6 729 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAELNTHVNV	KEKIYAVRSV	VPNKSNNEIV	LVLQQFDFNV	DKAVQAFVDG
SAIQVLKEWN	MTGKKKNNKR	KRSKSKQHQG	NKDAKDKVER	PEAGPLQPQP
PQIQNGPMNG	CEKDSSSTDS	ANEKPALIPR	EKKISILEEP	SKALRGVTEG
NRLLQQKLSL	DGNPKPIHGT	TERSDGLQWS	AEQPCNPSKP	KAKTSPVKSN
TPAAHLEIKP	DELAKKRGPN	IEKSVKDLQR	CTVSLTRYRV	MIKEEVDSSV
KKIKAAFAEL	HNCIIDKEVS	LMAEMDKVKE	EAMEILTARQ	KKAEELKRLT
DLASQMAEMQ	LAELRAEIKH	FVSERKYDEE	LGKAARFSCD	IEQLKAQIML
CGEITHPKNN	YSSRTPCSSL	LPLLNAHAAT	SGKQSNFSRK	SSTHNKPSEG
KAANPKMVSS	LPSTADPSHQ	TMPANKQNGS	SNQRRRFNPQ	YHNNRLNGPA
KSQGSGNEAE	PLGKGNSRHE	HRRQPHNGFR	PKNKGGAKNQ	EASLGMKTPE
APAHSEKPRR	RQHAADTSEA	RPFRGSVGRV	SQCNLCPTRI	EVSTDAAVLS
VPAVTLVA

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000119042 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038331 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ "Entrez Gene: DNAPTP6 DNA polymerase-transactivated protein 6".
↑ "UniProt, Q9NUQ6" (jezik: engleski). Pristupljeno 19. 11. 2012.

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119042 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038331 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: DNAPTP6 DNA polymerase-transactivated protein 6".

[UniProt-7] "UniProt, Q9NUQ6" (jezik: engleski). Pristupljeno 19. 11. 2012.

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