GNL3L

GNL3L
Identifikatori
Aliasi	GNL3L
Vanjski ID-jevi	OMIM: 300873 MGI: 2448557 HomoloGene: 134538 GeneCards: GNL3L
Lokacija gena (čovjek) Hrom. Hromosom X Bend Xp11.22 Početak 54,530,183 bp Kraj 54,621,521 bp
Lokacija gena (miš) Hrom. Hromosom X (miš) Bend X|X F3 Početak 149,766,137 bp Kraj 149,800,318 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • nucleotide binding • GTP binding • vezivanje sa RNK • GO:0006184 GTPase activity Ćelijska komponenta • jedro • telomerase holoenzyme complex • membrana • Jedarce • citosol Biološki proces • regulation of protein stability • negative regulation of telomere maintenance via telomerase • positive regulation of protein homodimerization activity • negative regulation of protein sumoylation • positive regulation of protein localization to chromosome, telomeric region • negative regulation of protein ubiquitination • negative regulation of protein binding • ribosome biogenesis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	54552	237107
Ensembl	ENSG00000130119	ENSMUSG00000025266
UniProt	Q9NVN8	Q6PGG6
RefSeq (mRNK)	NM_001184819 NM_019067	NM_001168600 NM_198110
RefSeq (bjelančevina)	NP_001171748 NP_061940	NP_001162071 NP_932778
Lokacija (UCSC)	Chr X: 54.53 – 54.62 Mb	Chr X: 149.77 – 149.8 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

G jedarcetov protein 3-liki je protein koji je kod ljudi kodiran genom GNL3L.

Funkcija

Protein koji kodira ovaj gen jedarcetova GTPaza je neophodan za preradu ribosomske prerRNK i proliferaciju ćelija. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju isti protein.

Dopunska literatura

• Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
• Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
• Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916.
• Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
• Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
• Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLoS ONE. 10 (8): e0135845. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.